Perinuclear dot-like staining pattern
WebMar 9, 2016 · Thus, the perinuclear, dot-like staining pattern is reliable phenotypic characteristic of FGF23 expression. Similar perinuclear staining patterns of other markers … WebSOX10 is typically negative in both MCC and in cells infected with the Merkel cell polyomavirus. 3 Although perinuclear dot-like SOX10 staining has not been reported in …
Perinuclear dot-like staining pattern
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WebImmunohistochemistry with desmin: perinuclear dot-like staining (arrow). Source publication An Unusual Presentation of Desmoplastic Small Round Cell Tumour of the … WebMay 19, 2015 · The Topo I-like pattern can comprise staining of five subcellular regions: 1) Prominent fine speckled nuclear staining in interphase cells. 2) Consistent strong fine speckled staining of condensed chromatin in mitotic cells. Depending on the serum dilution used, the mitotic chromatin staining may appear homogeneous.
WebNov 15, 2012 · Studies demonstrate that CD99 positive cells show paranuclear dot-like immunoreactivity in PC [40] [41] [42]. In addition, pancreatic solid-pseudopapillary neoplasms show an exclusive dot-like... WebMar 9, 2016 · Similar perinuclear staining patterns of other markers have been observed during the immunohistochemical analyses of several other tumor types, including Merkel cell carcinoma (cytokeratin 20) [ 21 ], desmoplastic small round cell tumors (desmin) [ 22 ], and Hodgkin’s lymphoma (CD30) [ 23 ].
WebOne reported case with minimal desmoplasia was negative for WT1 and CD99 and had only 5% staining with EMA and patchy weak desmin staining with "scanty" perinuclear dot-like positivity [26 ... WebCK20 staining showing the characteristic perinuclear dot-like positivity Source publication +3 Merkel cell carcinoma: A review and update on aetiopathogenesis, diagnosis and treatment...
WebCytokeratin-20 (CK-20) is highly sensitive marker for MCC and it is positive in about 89-100% of cases, demonstrating a characteristic perinuclear dot-like staining pattern in tumor cells. Along with CK-20, MCC often stains positively with low molecular weight cytokeratin (CAM-5), neuron specific enolase (NSE) and synaptophysin.
WebA cytokeratin rim or perinuclear dot-like staining pattern is characteristic of SCLC and occasionally noted in LCNEC. 26 A significant proportion (>90%) of SCLC and ~50% of LCNEC express TTF-1; however, TTF-1 is not specific for pulmonary SCLC/LCNEC and can be expressed in extrapulmonary NEC. 1,33 Meanwhile, Napsin A staining excludes SCLC but ... grapeseed spa south coast wineryWebPerinuclear Dot-Like Cytokeratin 20 Staining in Small Cell N... : Applied Immunohistochemistry & Molecular Morphology. Primary ovarian small cell carcinomas … chip putt clay ballardWebMar 1, 2024 · MUC5AC expression in ALK + cancers was exclusively visualized through cytoplasmic staining (100%), whereas EGFR-mutated cancers showed predominantly perinuclear dot-like patterns (90.5%) and focal cytoplasmic staining (9.5%). MUC2 and MUC6 expression was not detected in either type of lung cancer. chip putty downloadWebn of immunohistochemical expression of ALK in EFH in the literature thus far describes both granular cytoplasmic staining and nuclear staining. We present a case of EFH with dot-like Golgi pattern perinuclear ALK expression, a previously undescribed staining pattern. We surmised this unique staining pattern could be due to a novel fusion partner, and using … grape seed spray oilWeb(D) A histologic slide showed cohesive tumor cells with round-shaped nuclei and a fine chromatin pattern (magnification ×200). (E,F) An immunohistochemical study demonstrated a perinuclear and/or dot-like staining pattern for CK20 (E) and a nuclear staining pattern for INSM1 (F). ((E,F), ×400). The inguinal lymph node biopsy was diagnosed as ... grape seeds rustic minecraftWebAug 1, 2024 · Positive staining with LCA (CD45) and/or vimentin, but negative staining for S100 and CK, indicates lymphoid lineage, with high sensitivity and specificity for lymphoid malignancies. 7, 8 However, a large percentage of lymphoblastic leukemias are frequently negative for LCA, 9, 10 with unpredictable and frequently negative staining patterns in … chip putt and drive contest at augustaWebSpectrins are a family of cytoskeletal proteins that organize and link membranes to subcellular motors and filaments. Although traditionally divided into erythroid and non-erythroid forms, the discovery of new spectrin isoforms in various tissues indicates that their distribution is not yet fully characterized. To our knowledge, there is no comprehensive … chip putty