Myc phosphorylation
Web28 jan. 2024 · To study the role of endogenous Myc T244 phosphorylation, we developed an anti–phospho-T244 Myc mouse monoclonal antibody, which readily demonstrated … WebSmall molecule inhibitors of aurora kinases are currently being investigated in oncology clinical trials. The long-term effects of these inhibitors on proliferating euploid cells have not been adequately studied. We examined the effect of the reversible pan-aurora kinase inhibitor VX-680 on p53-competent human euploid cells. Circumscribed treatment with …
Myc phosphorylation
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Web9 dec. 2024 · Phosphorylation on Ser62 of c-Myc increases its transcriptional activity (Farrell and Sears, 2014). Phosphorylation level of c-Myc was significantly reduced in … WebThe Abnormal Metabolism of Cancer Cells: Glycolysis Versus Oxidative Phosphorylation (OXPHOS) and Beyond. The distinct metabolic behaviors of cancer cells have been …
Web9 aug. 2024 · Phosphorylation of Ser-62 MYC by extracellular receptor kinase (ERK) and cyclin-dependent protein kinase 2 (CDK2) lead to stabilizing MYC whereas Thr-58 phosphorylation by glycogen synthase kinase (GSK-3β) results in degradation of MYC through the ubiquitin–proteasome pathway [ 40 ]. WebIn lung adenocarcinoma induced by c-myc, the expression of hexokinase-2 in mitochondrial was up-regulated near 5-fold and contributed significantly to the apoptosis inhibition. 31 In Burkitt’s lymphoma, it was reported by Kim et al that dysregulated c-myc collaborated with HIF-1α to induce hexokinase-2 overexpression and resulted in the metabolic switches to …
Web28 jan. 2024 · Phosphorylation-dependent Myc degradation driven by the SCF Fbw7 ubiquitin ligase is commonly targeted by mutations in cancers. Fbw7 is a substrate receptor of an SCF (Skp1/Cul1/F-box protein) ubiquitin ligase that binds to phosphorylated substrates via its β-propeller WD40 domain and to the rest of the SCF complex through its F-box … WebMYC and MCL1 increased mitochondrial oxidative phosphorylation (mtOXPHOS) and the generation of reactive oxygen species (ROS), processes involved in maintenance of …
Web10 feb. 2024 · Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis. Deregulation of MYC plays an essential role in T cell …
WebThe c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and … dnd monster cubeWebThe path of MYC from phosphorylation to degradation. (1) MYC is phosporylated by ERK on serine 62 (S62), resulting in stabilization of MYC. (2) Once MYC is phosphorylated pn … dnd monster from the elemental plane of chaosWeb1 jun. 2024 · MYC stability is regulated through phosphorylation: phosphorylation at Thr58 signals degradation while Ser62 phosphorylation leads to its stabilization and … dnd monster initiativeWeb11 jun. 2024 · Under normal physiological condition, MYC is an unstable protein with a half-life less than 15–30 min whereas in growth stimulated cells, MYC is transiently stabilized … dnd monster manual 5Web2 apr. 2013 · In vivo xenograft studies revealed that c-Myc phosphorylation by PKCζ is a critical event in the control of metastasis. Collectively, these results establish PKCζ as an … dnd monster hunter\u0027s packWeb31 okt. 2013 · MYC has long been appreciated as a nuclear phosphoprotein, however, the functional significance of MYC phosphorylation at a number of residues remains to be … dnd monster girl encyclopediaWeb9 dec. 2024 · Phosphorylation level of c-Myc was significantly reduced in KO PyVT tumors ( Figure 5 B and C), KO PyVT cells ( Figure 5 D), and α5 (IV) collagen-knockdown ( Supplementary Figure S4B ), DDR1-knockdown ( Figure 4 G), and ERα-knockdown ( Supplementary Figure S2G) breast cancer cells. create directory windows terminal