WebFeb 9, 2013 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (42,047,761 articles, preprints and more) When using FeHIF, solubilities were determined in the micellar layer of FeHIF, i.e. after removing the upper (lipid) layer (standard procedure), as well as in total FeHIF (without removal of the upper layer). Compound concentrations were determined using HPLC-UV/fluorescence. To link the solubilizing capacity with the ultrastructure, all human ...
A review of drug solubility in human intestinal fluids: Implications ...
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Solubility Profiling of HIV Protease Inhibitors in Human …
WebIn addition to individual intestinal fluid components, colloidal structures are responsible for enhancing the solubility of lipophilic compounds. The present study investigated the link … Webmedium; FaHIF, Fasted-state human intestinal fluid; FeHIF, Fed-state human intestinal fluid; FaSSIF, Fasted-state simulated intestinal fluid; FeSSIF, Fed-state simulated intestinal fluid; GI, Gastrointesti-nal; Log D, Logarithm of pH-adjusted partition coefficient between octanol and water; Log D6.5, Logarithm of pH-adjusted partition WebThe aim of this study was to determine the stability of three ester prodrugs, chloramphenicol succinate, enalapril and candesartan cilexetil, in human proximal small intestinal fluid (HIF), dog proximal small intestinal fluids (DIF) and simulated intestinal fluid (FaSSIF), with the addition of pancreatin. henry howell homes case