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WebMixing alcohol with certain medications can cause nausea and vomiting, headaches, drowsiness, fainting, or loss of coordination. It also can put you at risk for internal bleeding, heart problems, and difficulties in breathing. WebJan 26, 2024 · Methotrexate is known to cause severe drug interactions when taken with many types of medications. 3 Those taking methotrexate should be aware of the drug interactions and speak with their healthcare provider about the drugs or supplements they are taking prior to starting treatment with methotrexate. NSAIDs chad baker attorney toledo

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