WebFifteen nanometer thick films of Tpy-Pt–DNA complexes in a molar ratio of 5 : 1 were irradiated with monoenergetic electrons of 5 and 10 eV, which ... At both energies, the effective yields of crosslinks (CLs), base damage (BD) related CLs, single and double strand breaks (SSBs and DSBs), non-DSB-cluster lesions, loss of ... WebNEK1 is also involved in tumorigenesis, DNA repair machinery regulation and cilia formation. Several lead compounds were identified for NEKs human protein kinases in this project …
FANCD2-associated nuclease 1, but not exonuclease 1 or flap
WebA proportion of DNA modifications are caused by exogenous agents, both physical (namely ultraviolet sunlight and ionizing radiation) and chemical (such as benzopyrene, alkylating … WebThey are typically used to form intramolecular crosslinks or to prepare polymers from monomers. Heterobifunctional crosslinking reagents have different reactive groups such … pros of restricting population growth
Frontiers Targeting DNA-Protein Crosslinks via Post …
WebDrugs that produce DNA interstrand crosslinks (ICLs), between the two complementary strands of the double helix, have an important role in chemotherapy regimens for cancer. … WebSep 15, 2016 · DNA interstrand crosslinks (ICLs), inhibit DNA metabolism by covalently linking two strands of DNA and are formed by antitumor agents such as cisplatin and nitrogen mustards. WebSep 11, 2015 · Cisplatin and its derivatives, nitrogen mustards and mitomycin C, are used widely in cancer chemotherapy. Their efficacy is linked primarily to their ability to generate DNA interstrand cross-links (ICLs), which effectively block the progression of transcription and replication machineries. Release … pros of remote patient monitoring