Cisplatin induced cardiotoxicity

Author: cmlq

August undefined, 2024

WebHowever, it has a wide variety of side effects such as hepato, gastrointestinal, neuro, nephro, and cardiotoxicity (acute and/or chronic) th … The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity in experimental rats WebCancer therapy can result in cardiac toxicity, such as cardiomyopathy. Cardiotoxicity with chemotherapeutic agents in the form of cardiomyopathy was first described in 1966 in patients receiving anthracyclines. 1 However, cancer treatment–induced arrhythmia (CTIA) has not attracted specific attention until recently. 2.

Quercetin Mitigates Cisplatin-Induced Oxidative Damage and

WebAug 17, 2024 · Cisplatin-induced cardiotoxicity has been reported to mainly include arrhythmia, acute myocardial infarction, supraventricular tachycardia, and atrial fibrillation … WebOct 20, 2024 · Breast Milk mesenchymal stem cells (Br-MSCs) are a non-invasive, highly reproducible source of stem cells. Herein, we investigate Br-MSCs' role in cardiotoxicity induced by cisplatin. diary of a wimpy kid cast patty

(PDF) Cisplatin-induced cardiotoxicity – two case reports

WebSep 15, 2024 · Cisplatin's side effects primarily include nephrotoxicity, gastrointestinal toxicity, neurotoxicity and ototoxicity. Cardiotoxicity is generally not defined as a side effect of cisplatin. However, over the past decade there has been a surge in the amount of clinical cases reporting a vast array of cardio-toxic events occurring during or shortly ... WebApr 14, 2024 · While the exact mechanisms underlying the relationship between gut microbiota and chemotherapy-induced cardiotoxicity are not yet fully understood, these findings suggest that targeting the microbiome may be a promising strategy for mitigating the cardiovascular side effects of cancer treatment. ... observed that cisplatin, one of the ... WebApr 7, 2024 · This present study investigated the protective effects of asperuloside (ASP) against cadmium-induced nephrocardiac toxicity. Rats were treated with 50 mg/kg of ASP for five weeks and CdCl 2 (5 mg ... diary of a wimpy kid chapter summary

Exploring the Involvement of Gut Microbiota in Cancer Therapy …

The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs …

WebDec 30, 2015 · El-Awady el-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Eur Eur J … WebAfter right heart catheterization, pathological results of a myocardial biopsy from the ventricular septum indicated no cardiac muscle hypertrophy, cardiac fibrosis, inflammatory cell infiltration, or myocyte disarray. Eventually, she was diagnosed as having pemetrexed-induced cardiomyopathy. cities on flames blue oyster cultWebFeb 6, 2024 · Abstract. The cardiotoxicity of chemotherapeutic drugs as cisplatin has become a major issue in recent years. The present study investigates the efficacy of … diary of a wimpy kid cgi movie rodrick rules

"WebFeb 21, 2024 · Cardiotoxicity of trastuzumab and other HER2-targeted agents; Cisplatin nephrotoxicity; Clinical manifestations, diagnosis, and treatment of anthracycline-induced cardiotoxicity; Drug-induced thrombotic microangiopathy (DITMA) Endocrine therapy … " - Cisplatin induced cardiotoxicity

Cisplatin induced cardiotoxicity

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WebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP … WebCisplatin-induced cardiotoxicity is rare, and the prevalence remains unknown. Jakubowski and Kemeny showed that cardiotoxicity occurs in 6% of the patients …

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WebJun 1, 2013 · At present, no data is provided explaining the mechanism of NO in cisplatin-induced cardiotoxicity. It has been found that NO and its metabolites, including … WebDec 1, 2024 · Cisplatin is a highly effective antitumor agent. However, its use is limited due to severe adverse effects, particularly nephrotoxicity, which occurs in approximately 30% of patients. There is a need for novel renoprotective compounds.

WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al., 2024 WebThe current study aimed to investigate the curative role of semaglutide's against cisplatin- induced cardiotoxicity and its relation to mitochondrial functions, dynamics, biogenesis, apoptosis, and redox status pathways. The study included 30 male rats divided into three groups: control, cisplatin-induced cardiotoxicity, and cisplatin-induced ...

WebAug 17, 2024 · Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway Front Pharmacol. 2024 Aug 17;12:711238. doi: 10.3389/fphar.2024.711238. eCollection 2024. Authors WebSep 1, 2024 · Cisplatin-induced cardiotoxicity severely limits its clinical application as an antitumor drug and increases the risk of cardiovascular disease. Icariin (ICA), the main …

WebDrug-induced cardiotoxicity limits or forbids further use of the implicated drugs. Such drugs that are currently available in the clinic include anti-tumor drugs (doxorubicin, cisplatin, trastuzumab, etc.), antidiabetic drugs (rosiglitazone and pioglitazone), and an antiviral drug (zidovudine).

WebOct 1, 2024 · Cardiotoxicity of chemotherapy exerts as the main hurdle for prognosis, while whether cisplatin causes severe cardiotoxicity remains largely unknown. Accum … cities on gmtWebCardiotoxicity has also been linked to cisplatin treatment. The leakages of lactate dehydrogenase (LDH) as well as creatine kinase from the cardiac myocytes result from Cardiotoxicity. 39 This could be secondary processes that results from cisplatin-induced lipid peroxidation or cardiac membranes. cities on flame lyrics blue oyster cultWebAug 31, 2024 · However, the mechanism of CDDP-induced cardiotoxicity is poorly understood. Acetyl-l-carnitine (ALCAR) is an antioxidant agent with protective effects against the side effects of various chemotherapeutics. CDDP-induced cardiotoxicity and the protective role of ALCAR were evaluated in this study. cities on flame with rock n rollWebJan 10, 2011 · Cisplatin-induced cardiotoxicity Acetyl-l-carnitine DL-α-lipoic acid Silymarin Mitochondrial DNA Apoptosis 1. Introduction Cisplatin is one of the most remarkable successes in ‘the war on cancer’. Since the accidental discovery four decades ago, cisplatin has been widely used for chemotherapy. cities on georgia mapWebCardioprotective effect of zingerone against oxidative stress, inflammation, and apoptosis induced by cisplatin or gamma radiation in rats Despite their clinical benefits in cancer treatment, the deleterious effects on heart following chemo/radiotherapy are of increasing importance. diary of a wimpy kid cg movieWebRats treated with rhEPO, simultaneously, before, or after Cisp injection, remarkably decreased DNA damage, highlighting an interesting cytoprotective strategy usingrhEPO against Cisp-induced liver and heart injuries. Cisplatin (Cisp) is one of the most effective chemotherapeutic agents. However, at higher doses, liver and heart injuries may occur. … cities on i 10 in texasWebNational Center for Biotechnology Information diary of a wimpy kid character creator